MIC1-MAG1-SAG1 Chimeric Protein, a Most Effective Antigen for Detection of Human Toxoplasmosis
نویسندگان
چکیده
منابع مشابه
Recombinant MAG1 Protein of Toxoplasma gondii as a Diagnostic Antigen.
The aim of this study was to evaluate the potential diagnostic usefulness of the full-length recombinant Toxoplasma gondii MAG1 protein by determining the levels of specific IgM and IgG antibodies in mouse and human sera obtained from individuals with acute and chronic toxoplasmosis. The obtained results revealed that IgG antibodies against MAG1 are a sensitive and specific marker of T. gondii ...
متن کاملDevelopment and Clinical Evaluation of a Rapid Serodiagnostic Test for Toxoplasmosis of Cats Using Recombinant SAG1 Antigen
Rapid serodiagnostic methods for Toxoplasma gondii infection in cats are urgently needed for effective control of transmission routes toward human infections. In this work, 4 recombinant T. gondii antigens (SAG1, SAG2, GRA3, and GRA6) were produced and tested for the development of rapid diagnostic test (RDT). The proteins were expressed in Escherichia coli, affinity-purified, and applied onto ...
متن کاملThe SAG1 Toxoplasma gondii surface protein is not required for acute ocular toxoplasmosis in mice.
The SAG1 Toxoplasma gondii surface protein stimulates acute ileitis. To determine whether SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were injected intravitreally into mice. No differences in retinal damage or parasite growth were observed, indicating that unlike the case for the intestine, factors besides SAG1 are important for retinal damage.
متن کاملProduction of MAG1 Antigen of Toxoplasma gondii in Escherichia coli
Introduction : Toxoplasmosis is a parasitic infection caused by the protozoan Toxoplasma gondii it leads to serious medical problems in congenitally-infected and immunocompromised individuals, while it is quite harmless in immunocompetent individuals. Toxoplasma tissue cyst matrix protein (MAG1) induces early humoral and cell-mediated immune responses. Previous studies suggested recombinant M...
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Introduction: Nowadays, we are witnessing an exponential use of interventional radiology techniques in different communities. After CT, interventional techniques are the second factor of increasing patients’ doses in different societies. Measuring patient doses from aforementioned methods has been recommended by many radiation protection professional organizations such as ICRP...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2012
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00452-12